AOD-9604

5mg Vial, Needs Acetic Acid Solution

Mechanism of action:

AOD‑9604 is a 16‑amino‑acid peptide corresponding to the lipolytic region of the hGH C‑terminus, designed to retain fat‑metabolism effects without classical GH receptor activation. In obese mice, chronic administration reduces body weight and fat mass, increases fat oxidation, and up‑regulates beta‑3 adrenergic receptor mRNA in adipose tissue, without reproducing full hGH growth‑promoting effects.

The peptide appears to stimulate lipolysis and inhibit lipogenesis in adipocytes and increases energy expenditure, with animal data suggesting it does not significantly impair insulin sensitivity compared with intact hGH. In vitro and review work describe it as selectively activating lipid metabolism pathways in adipose tissue, while sparing IGF‑1 and linear growth axes, although the precise receptor‑level mechanism remains incompletely defined.