How many of us are all gas and no breaks during prep and crushing estrogen going into a bodybuilding show? 

For me personally, during the last week my lack of estrogen made my ADD unbearable.  I’m not talking about the lack of energy or focus due to being low carb and depleted as your brains primary fuel source is glucose.

I couldn’t focus without heavy nootropic or adderall (I have a rx for it) use.  My brain was jumping around and it was frustrating the Hell out of me as I am a very structured individual. My mood went to shit as a result.

The reason? Well aside from Glucose your brain needs estrogen as well, which I bet many of you didn’t know!

Estrogen and Brain Function

Estrogen plays a key role in brain health:

• Neuroprotection: Reduces oxidative stress and inflammation

• Synaptic plasticity: Supports learning and memory

• Mitochondrial function: Enhances energy metabolism in neurons

So, blocking estrogen could affect cognitive and neurological functions.

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⚠️ Potential Neurotoxic or Cognitive Effects

1. Cognitive Impairment

• Tamoxifen and aromatase inhibitors have been associated with:

• Memory loss

• Brain fog

• Executive function decline

• Especially seen in postmenopausal women on long-term treatment

2. Mood Disorders

• Anti-estrogens may increase risk of depression, anxiety, and irritability

• Estrogen has mood-stabilizing properties, and blocking it can lead to mood swings

3. Neurotoxicity in Animal Models

• Some rodent studies show neuronal damage, reduced neurogenesis, and oxidative stress with long-term anti-estrogen exposure.

So what are we to do? We need that hard, dry look after all!

Lions Mane – check out our mushroom blend!

J-147 is also a great nootropic option as it reduces inflammation, promotes growth of new neurons and synaptic plasticity, and boosts BDNF.

Keep up on your antioxidants, I would be remiss if I didn’t mention we offer a potent antioxidant blend.